A generally applicable systems medical strategy to find novel diagnostic markers and therapeutic targets

CASyM partner Mikael Benson from the Centre for Individualized Medicine, Linköping University, Sweden: Medical research is focused on individual genes and diseases. By contrast, a recent systems medical article in Science Translational Medicine shows the pathogenic, diagnostic and therapeutic relevance of studying multiple genes and diseases: A generally applicable analytical strategy was developed that integrated omics, bioinformatics, functional and clinical studies. This showed that a drug target in cancer and autoimmune diseases, S100A4, is also diagnostic and therapeutic target in allergy. The article was based on previous work from the MultiMod project that resulted in publications in Nature Genetics, Genome Biology and Plos Genetics that are found on the website. A reprint of the Science Translational Medicine article is available here.

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